Design and synthesis of formononetin-dithiocarbamate hybrids that inhibit growth and migration of PC-3 cells via MAPK/Wnt signaling pathways

A series of novel formononetin-dithiocarbamate derivatives were designed, synthesized and evaluated for antiproliferative activity against three selected cancer cell line (MGC-803, EC-109, PC-3). The first structure-activity relationship (SAR) for this formononetin-dithiocarbamate scaffold is explor...

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Enregistré dans:
Détails bibliographiques
Publié dans:Eur J Med Chem
Auteurs principaux: Fu, Dong-Jun, Zhang, Li, Song, Jian, Mao, Ruo-Wang, Zhao, Ruo-Han, Liu, Ying-Chao, Hou, Yu-Hui, Li, Jia-Huan, Yang, Jia-Jia, Jin, Cheng-Yun, Li, Ping, Zi, Xiao-Lin, Liu, Hong-Min, Zhang, Sai-Yang, Zhang, Yan-Bing
Format: Artigo
Langue:Inglês
Publié: 2016
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5567725/
https://ncbi.nlm.nih.gov/pubmed/28038329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2016.12.027
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