Generation of pure GABAergic neurons by transcription factor programming

Approaches to differentiating pluripotent stem cells (Pscs) into neurons currently face two major challenges—(i) generated cells are immature, with limited functional properties; and (ii) cultures exhibit heterogeneous neuronal subtypes and maturation stages. using lineage-determining transcription...

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Bibliografiska uppgifter
I publikationen:Nat Methods
Huvudupphovsmän: Yang, Nan, Chanda, Soham, Marro, Samuele, Ng, Yi-Han, Janas, Justyna A, Haag, Daniel, Ang, Cheen Euong, Tang, Yunshuo, Flores, Quetzal, Mall, Moritz, Wapinski, Orly, Li, Mavis, Ahlenius, Henrik, Rubenstein, John L, Chang, Howard Y, Buylla, Arturo Alvarez, Südhof, Thomas C, Wernig, Marius
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5567689/
https://ncbi.nlm.nih.gov/pubmed/28504679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.4291
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