Beta-arrestin 2 rather than G protein efficacy determines the anxiolytic-versus antidepressant-like effects of nociceptin/orphanin FQ receptor ligands

BACKGROUND AND PURPOSE: Nociceptin/orphanin FQ (N/OFQ) receptor (NOP) agonists produce anxiolytic-like effects in rodents while antagonists promote antidepressant-like effects. The aim of this study was to investigate the effect on anxiety and depression of NOP receptor partial agonists such as the...

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Bibliographic Details
Published in:Neuropharmacology
Main Authors: Asth, L, Ruzza, C, Malfacini, D, Medeiros, I, Guerrini, R, Zaveri, N.T., Gavioli, E.C., Calo', G
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5567672/
https://ncbi.nlm.nih.gov/pubmed/26867504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2016.02.003
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