Characterization and structural determination of a new anti-MET function-blocking antibody with binding epitope distinct from the ligand binding domain

The growth and motility factor Hepatocyte Growth Factor/Scatter Factor (HGF/SF) and its receptor, the product of the MET proto-oncogene, promote invasion and metastasis of tumor cells and have been considered potential targets for cancer therapy. We generated a new Met-blocking antibody which binds...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: DiCara, Danielle M., Chirgadze, Dimitri Y., Pope, Anthony R., Karatt-Vellatt, Aneesh, Winter, Anja, Slavny, Peter, van den Heuvel, Joop, Parthiban, Kothai, Holland, Jane, Packman, Len C., Mavria, Georgia, Hoffmann, Jens, Birchmeier, Walter, Gherardi, Ermanno, McCafferty, John
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2017
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5567289/
https://ncbi.nlm.nih.gov/pubmed/28827556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09460-2
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires