Characterization and structural determination of a new anti-MET function-blocking antibody with binding epitope distinct from the ligand binding domain

The growth and motility factor Hepatocyte Growth Factor/Scatter Factor (HGF/SF) and its receptor, the product of the MET proto-oncogene, promote invasion and metastasis of tumor cells and have been considered potential targets for cancer therapy. We generated a new Met-blocking antibody which binds...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: DiCara, Danielle M., Chirgadze, Dimitri Y., Pope, Anthony R., Karatt-Vellatt, Aneesh, Winter, Anja, Slavny, Peter, van den Heuvel, Joop, Parthiban, Kothai, Holland, Jane, Packman, Len C., Mavria, Georgia, Hoffmann, Jens, Birchmeier, Walter, Gherardi, Ermanno, McCafferty, John
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5567289/
https://ncbi.nlm.nih.gov/pubmed/28827556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09460-2
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