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The open architecture of HD-PTP phosphatase provides new insights into the mechanism of regulation of ESCRT function
HD-PTP is a tumour suppressor phosphatase that controls endocytosis, down-regulation of mitogenic receptors and cell migration. Central to its role is the specific recruitment of critical endosomal sorting complexes required for transport (ESCRTs). However, the molecular mechanisms that enable HD-PT...
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| Publicado en: | Sci Rep |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5567221/ https://ncbi.nlm.nih.gov/pubmed/28831121 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09467-9 |
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