Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state.

The microtubule-associated protein tau is a major component of the paired helical filaments (PHFs) observed in Alzheimer's disease brains. The pathological tau is distinguished from normal tau by its state of phosphorylation, higher apparent M(r) and reaction with certain antibodies. However, t...

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Autores principales: Drewes, G, Lichtenberg-Kraag, B, Döring, F, Mandelkow, E M, Biernat, J, Goris, J, Dorée, M, Mandelkow, E
Formato: Artigo
Lenguaje:Inglês
Publicado: 1992
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC556680/
https://ncbi.nlm.nih.gov/pubmed/1376245
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