Chargement en cours...

Stepwise proteolysis liberates tau fragments that nucleate the Alzheimer-like aggregation of full-length tau in a neuronal cell model

Tau is a highly soluble protein, yet it aggregates abnormally in Alzheimer's disease. Here, we address the question of proteolytic processing of tau and the nucleation of aggregates by tau fragments. We show in neuronal cell models that fragments of the repeat domain of tau containing mutations...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Wang, Y. P., Biernat, J., Pickhardt, M., Mandelkow, E., Mandelkow, E.-M.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2007
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1891218/
https://ncbi.nlm.nih.gov/pubmed/17535890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0703676104
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!