Gabapentin Modulates HCN4 Channel Voltage-Dependence

Gabapentin (GBP) is widely used to treat epilepsy and neuropathic pain. There is evidence that GBP can act on hyperpolarization-activated cation (HCN) channel-mediated I(h) in brain slice experiments. However, evidence showing that GBP directly modulates HCN channels is lacking. The effect of GBP wa...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Tae, Han-Shen, Smith, Kelly M., Phillips, A. Marie, Boyle, Kieran A., Li, Melody, Forster, Ian C., Hatch, Robert J., Richardson, Robert, Hughes, David I., Graham, Brett A., Petrou, Steven, Reid, Christopher A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5566583/
https://ncbi.nlm.nih.gov/pubmed/28871229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00554
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