The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region.

Ítems similars

• Phosphorylation-dependent epitopes of neurofilament antibodies on tau protein and relationship with Alzheimer tau.
  per: Lichtenberg-Kraag, B, et al.
  Publicat: (1992)
• The Development of Cell Processes Induced by tau Protein Requires Phosphorylation of Serine 262 and 356 in the Repeat Domain and Is Inhibited by Phosphorylation in the Proline-rich Domains
  per: Biernat, Jacek, et al.
  Publicat: (1999)
• Domains of tau protein, differential phosphorylation, and dynamic instability of microtubules.
  per: Trinczek, B, et al.
  Publicat: (1995)
• Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state.
  per: Drewes, G, et al.
  Publicat: (1992)
• Repeat motifs of tau bind to the insides of microtubules in the absence of taxol
  per: Kar, Santwana, et al.
  Publicat: (2003)