The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region.

The paired helical filaments (PHFs) of Alzheimer's disease consist mainly of the microtubule-associated protein tau. PHF tau differs from normal human brain tau in that it has a higher Mr and a special state of phosphorylation. However, the protein kinase(s) involved, the phosphorylation sites...

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Autores principales: Biernat, J, Mandelkow, E M, Schröter, C, Lichtenberg-Kraag, B, Steiner, B, Berling, B, Meyer, H, Mercken, M, Vandermeeren, A, Goedert, M
Formato: Artigo
Lenguaje:Inglês
Publicado: 1992
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC556608/
https://ncbi.nlm.nih.gov/pubmed/1563356
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