The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region.

The paired helical filaments (PHFs) of Alzheimer's disease consist mainly of the microtubule-associated protein tau. PHF tau differs from normal human brain tau in that it has a higher Mr and a special state of phosphorylation. However, the protein kinase(s) involved, the phosphorylation sites on ta...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Biernat, J, Mandelkow, E M, Schröter, C, Lichtenberg-Kraag, B, Steiner, B, Berling, B, Meyer, H, Mercken, M, Vandermeeren, A, Goedert, M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC556608/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1563356/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1992.tb05204.x
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