Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS)

Fibrils and oligomers are the aggregated protein agents of neuronal dysfunction in ALS diseases. Whereas we now know much about fibril architecture, atomic structures of disease-related oligomers have eluded determination. Here, we determine the corkscrew-like structure of a cytotoxic segment of sup...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Sangwan, Smriti, Zhao, Anni, Adams, Katrina L., Jayson, Christina K., Sawaya, Michael R., Guenther, Elizabeth L., Pan, Albert C., Ngo, Jennifer, Moore, Destaye M., Soriaga, Angela B., Do, Thanh D., Goldschmidt, Lukasz, Nelson, Rebecca, Bowers, Michael T., Koehler, Carla M., Shaw, David E., Novitch, Bennett G., Eisenberg, David S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2017
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5565441/
https://ncbi.nlm.nih.gov/pubmed/28760994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1705091114
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