Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS)

Fibrils and oligomers are the aggregated protein agents of neuronal dysfunction in ALS diseases. Whereas we now know much about fibril architecture, atomic structures of disease-related oligomers have eluded determination. Here, we determine the corkscrew-like structure of a cytotoxic segment of sup...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Sangwan, Smriti, Zhao, Anni, Adams, Katrina L., Jayson, Christina K., Sawaya, Michael R., Guenther, Elizabeth L., Pan, Albert C., Ngo, Jennifer, Moore, Destaye M., Soriaga, Angela B., Do, Thanh D., Goldschmidt, Lukasz, Nelson, Rebecca, Bowers, Michael T., Koehler, Carla M., Shaw, David E., Novitch, Bennett G., Eisenberg, David S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5565441/
https://ncbi.nlm.nih.gov/pubmed/28760994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1705091114
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