Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways

Alzheimer’s disease (AD) is characterized by amyloid-β (Aβ) peptide deposition in brain parenchyma as plaques and in cerebral blood vessels as cerebral amyloid angiopathy (CAA). CAA deposition leads to several clinical complications, including intracerebral hemorrhage. The underlying molecular mecha...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Wojtas, Aleksandra M., Kang, Silvia S., Olley, Benjamin M., Gatherer, Maureen, Shinohara, Mitsuru, Lozano, Patricia A., Liu, Chia-Chen, Kurti, Aishe, Baker, Kelsey E., Dickson, Dennis W., Yue, Mei, Petrucelli, Leonard, Bu, Guojun, Carare, Roxana O., Fryer, John D.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5565413/
https://ncbi.nlm.nih.gov/pubmed/28701379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1701137114
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