Identification of plexin A4 as a novel clusterin receptor links two Alzheimer’s disease risk genes

Although abundant genetic and biochemical evidence strongly links Clusterin (CLU) to Alzheimer disease (AD) pathogenesis, the receptor for CLU within the adult brain is currently unknown. Using unbiased approaches, we identified Plexin A4 (PLXNA4) as a novel, high-affinity receptor for CLU in the ad...

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Gepubliceerd in:Hum Mol Genet
Hoofdauteurs: Kang, Silvia S., Kurti, Aishe, Wojtas, Aleksandra, Baker, Kelsey E., Liu, Chia-Chen, Kanekiyo, Takahisa, Deming, Yuetiva, Cruchaga, Carlos, Estus, Steven, Bu, Guojun, Fryer, John D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2016
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Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5179943/
https://ncbi.nlm.nih.gov/pubmed/27378688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw188
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