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Potential energy landscapes identify the information-theoretic nature of the epigenome

Epigenetics studies genomic modifications carrying information independent of DNA sequence heritable through cell division. In 1940, Waddington coined the term “epigenetic landscape” as a metaphor for pluripotency and differentiation, but methylation landscapes have not yet been rigorously computed....

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Détails bibliographiques
Publié dans:Nat Genet
Auteurs principaux: Jenkinson, Garrett, Pujadas, Elisabet, Goutsias, John, Feinberg, Andrew P.
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5565269/
https://ncbi.nlm.nih.gov/pubmed/28346445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3811
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