Ferroptosis and autophagy induced cell death occur independently after siramesine and lapatinib treatment in breast cancer cells

Ferroptosis is a cell death pathway characterized by iron-dependent accumulation of reactive oxygen species (ROS) within the cell. The combination of siramesine, a lysosome disruptor, and lapatinib, a dual tyrosine kinase inhibitor, has been shown to synergistically induce cell death in breast cance...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Ma, Shumei, Dielschneider, Rebecca F., Henson, Elizabeth S., Xiao, Wenyan, Choquette, Tricia R., Blankstein, Anna R., Chen, Yongqiang, Gibson, Spencer B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5565111/
https://ncbi.nlm.nih.gov/pubmed/28827805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0182921
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