Lysosomal Destabilizing Drug Siramesine and the Dual Tyrosine Kinase Inhibitor Lapatinib Induce a Synergistic Ferroptosis through Reduced Heme Oxygenase-1 (HO-1) Levels

Ferroptosis is an iron-dependent type of cell death distinct from apoptosis or necrosis characterized by accumulation of reactive oxygen species. The combination of siramesine, a lysosomotropic agent, and lapatinib, a dual tyrosine kinase inhibitor (TKI), synergistically induced cell death in breast...

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Опубликовано в: :Oxid Med Cell Longev
Главные авторы: Villalpando-Rodriguez, Gloria E., Blankstein, Anna R., Konzelman, Carmen, Gibson, Spencer B.
Формат: Artigo
Язык:Inglês
Опубликовано: Hindawi 2019
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6766165/
https://ncbi.nlm.nih.gov/pubmed/31636810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/9561281
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