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Histone demethylase JMJD3 regulates CD11a expression through changes in histone H3K27 tri-methylation levels in CD4(+) T cells of patients with systemic lupus erythematosus

Aberrant CD11a overexpression in CD4(+) T cells induces T cell auto-reactivity, which is an important factor for systemic lupus erythematosus (SLE) pathogenesis. Although many studies have focused on CD11a epigenetic regulation, little is known about histone methylation. JMJD3, as a histone demethyl...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Yin, Heng, Wu, Haijing, Zhao, Ming, Zhang, Qing, Long, Hai, Fu, Siqi, Lu, Qianjin
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5564738/
https://ncbi.nlm.nih.gov/pubmed/28430662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16894
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