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Histone demethylase JMJD3 regulates CD11a expression through changes in histone H3K27 tri-methylation levels in CD4(+) T cells of patients with systemic lupus erythematosus
Aberrant CD11a overexpression in CD4(+) T cells induces T cell auto-reactivity, which is an important factor for systemic lupus erythematosus (SLE) pathogenesis. Although many studies have focused on CD11a epigenetic regulation, little is known about histone methylation. JMJD3, as a histone demethyl...
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| Pubblicato in: | Oncotarget |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Impact Journals LLC
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5564738/ https://ncbi.nlm.nih.gov/pubmed/28430662 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16894 |
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