Protein drug target activation homogeneity in the face of intra-tumor heterogeneity: implications for precision medicine

Introduction: Recent studies indicated tumors may be comprised of heterogeneous molecular subtypes and incongruent molecular portraits may emerge if different areas of the tumor are sampled. This study explored the impact of intra-tumoral heterogeneity in terms of activation/phosphorylation of FDA a...

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Bibliografiska uppgifter
I publikationen:Oncotarget
Huvudupphovsmän: Parasido, Erika Maria, Silvestri, Alessandra, Canzonieri, Vincenzo, Belluco, Claudio, Diodoro, Maria Grazia, Milione, Massimo, Melotti, Flavia, De Maria, Ruggero, Liotta, Lance, Petricoin, Emanuel F., Pierobon, Mariaelena
Materialtyp: Artigo
Språk:Inglês
Publicerad: Impact Journals LLC 2016
Ämnen:
Priority Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5564706/
https://ncbi.nlm.nih.gov/pubmed/28159918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14019
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