Protein drug target activation homogeneity in the face of intra-tumor heterogeneity: implications for precision medicine

Introduction: Recent studies indicated tumors may be comprised of heterogeneous molecular subtypes and incongruent molecular portraits may emerge if different areas of the tumor are sampled. This study explored the impact of intra-tumoral heterogeneity in terms of activation/phosphorylation of FDA a...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Parasido, Erika Maria, Silvestri, Alessandra, Canzonieri, Vincenzo, Belluco, Claudio, Diodoro, Maria Grazia, Milione, Massimo, Melotti, Flavia, De Maria, Ruggero, Liotta, Lance, Petricoin, Emanuel F., Pierobon, Mariaelena
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2016
Sujets:
Priority Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5564706/
https://ncbi.nlm.nih.gov/pubmed/28159918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14019
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