Quantitative multiplex immunohistochemistry reveals myeloid-inflamed tumor-immune complexity associated with poor prognosis

Here we describe a multiplexed immunohistochemical platform, with computational image processing workflows including image cytometry, enabling simultaneous evaluation of 12 biomarkers in one formalin-fixed paraffin-embedded tissue section. To validate this platform, we used tissue microarrays contai...

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Dettagli Bibliografici
Pubblicato in:Cell Rep
Autori principali: Tsujikawa, Takahiro, Kumar, Sushil, Borkar, Rohan N., Azimi, Vahid, Thibault, Guillaume, Chang, Young Hwan, Balter, Ariel, Kawashima, Rie, Choe, Gina, Sauer, David, El Rassi, Edward, Clayburgh, Daniel R., Kulesz-Martin, Molly F., Lutz, Eric R., Zheng, Lei, Jaffee, Elizabeth M., Leyshock, Patrick, Margolin, Adam A., Mori, Motomi, Gray, Joe W., Flint, Paul W., Coussens, Lisa M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5564306/
https://ncbi.nlm.nih.gov/pubmed/28380359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.03.037
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