IFNγ-activated dermal lymphatic vessels inhibit cytotoxic T cells in melanoma and inflamed skin

Mechanisms of immune suppression in peripheral tissues counteract protective immunity to prevent immunopathology and are coopted by tumors for immune evasion. While lymphatic vessels facilitate T cell priming, they also exert immune suppressive effects in lymph nodes at steady-state. Therefore, we h...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Exp Med
Auteurs principaux: Lane, Ryan S., Femel, Julia, Breazeale, Alec P., Loo, Christopher P., Thibault, Guillaume, Kaempf, Andy, Mori, Motomi, Tsujikawa, Takahiro, Chang, Young Hwan, Lund, Amanda W.
Format: Artigo
Langue:Inglês
Publié: Rockefeller University Press 2018
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6279400/
https://ncbi.nlm.nih.gov/pubmed/30381467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20180654
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