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Radiation therapy causes loss of dermal lymphatic vessels and interferes with lymphatic function by TGF-β1-mediated tissue fibrosis

Although radiation therapy is a major risk factor for the development of lymphedema following lymphadenectomy, the mechanisms responsible for this effect remain unknown. The purpose of this study was therefore to determine the effects of radiation on lymphatic endothelial cells (LECs) and lymphatic...

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Detalhes bibliográficos
Main Authors: Avraham, Tomer, Yan, Alan, Zampell, Jamie C., Daluvoy, Sanjay V., Haimovitz-Friedman, Adriana, Cordeiro, Andrew P., Mehrara, Babak J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2944320/
https://ncbi.nlm.nih.gov/pubmed/20519446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00535.2009
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