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Radiation therapy causes loss of dermal lymphatic vessels and interferes with lymphatic function by TGF-β1-mediated tissue fibrosis

Although radiation therapy is a major risk factor for the development of lymphedema following lymphadenectomy, the mechanisms responsible for this effect remain unknown. The purpose of this study was therefore to determine the effects of radiation on lymphatic endothelial cells (LECs) and lymphatic...

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Hlavní autoři: Avraham, Tomer, Yan, Alan, Zampell, Jamie C., Daluvoy, Sanjay V., Haimovitz-Friedman, Adriana, Cordeiro, Andrew P., Mehrara, Babak J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2944320/
https://ncbi.nlm.nih.gov/pubmed/20519446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00535.2009
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