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Reactivity and Cross-Linking of 5′-Terminal Abasic Sites Within DNA
Nicking of the DNA strand immediately upstream of an internal abasic (AP) site produces 5′-terminal abasic (dRp) DNA. Both the intact and the nicked abasic species are reactive intermediates along the DNA base excision repair (BER) pathway and can be derailed by side reactions. Aberrant accumulation...
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| Publicado no: | Chem Res Toxicol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5564299/ https://ncbi.nlm.nih.gov/pubmed/28485930 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.7b00057 |
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