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Chaperone-mediated autophagy and neurodegeneration: connections, mechanisms, and therapeutic implications
Lysosomes degrade dysfunctional intracellular components via three pathways: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). Unlike the other two, CMA degrades cytosolic proteins with a recognized KFERQ-like motif in lysosomes and is important for cellular homeostasis. CMA ac...
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| Publicado no: | Neurosci Bull |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5563713/ https://ncbi.nlm.nih.gov/pubmed/26206600 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12264-015-1542-8 |
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