Chaperone-mediated autophagy and neurodegeneration: connections, mechanisms, and therapeutic implications

Lysosomes degrade dysfunctional intracellular components via three pathways: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). Unlike the other two, CMA degrades cytosolic proteins with a recognized KFERQ-like motif in lysosomes and is important for cellular homeostasis. CMA ac...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Neurosci Bull
Autori principali: Liu, Xiaolei, Huang, Sihua, Wang, Xingqin, Tang, Beisha, Li, Wenming, Mao, Zixu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 2015
Soggetti:
Review
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5563713/
https://ncbi.nlm.nih.gov/pubmed/26206600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12264-015-1542-8
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