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Evidence for Ig Light Chain Isotype Exclusion in Shark B Lymphocytes Suggests Ordered Mechanisms

Unlike most vertebrates, the shark IgL gene organization precludes secondary rearrangements that delete self-reactive VJ rearranged genes. Nurse sharks express four L chain isotypes, κ, λ, σ, and σ-2, encoded by 35 functional minigenes or clusters. The sequence of gene activation/expression and rece...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Iacoangeli, Anna, Lui, Anita, Haines, Ashley, Ohta, Yuko, Flajnik, Martin, Hsu, Ellen
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5563170/
https://ncbi.nlm.nih.gov/pubmed/28760881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700762
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