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Retrogradely trafficked TrkA endosomes signal locally within dendrites to maintain sympathetic neuron synapses

Sympathetic neurons require NGF from their target fields for survival, axonal target innervation, dendritic growth and formation, and maintenance of synaptic inputs from preganglionic neurons. Target-derived NGF signals are propagated retrogradely, from distal axons to somata of sympathetic neurons...

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Pubblicato in:Cell Rep
Autori principali: Lehigh, Kathryn M., West, Katherine M., Ginty, David D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5562950/
https://ncbi.nlm.nih.gov/pubmed/28380365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.03.028
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