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Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability

Several mutations in PTEN-induced putative kinase 1 (PINK1) gene have been reported to be associated with recessive parkinsonism. The encoded protein is predicted to be a Ser/Thr protein kinase targeted to mitochondria. In this study, we have investigated the effects of mutations on PINK1 kinase act...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Beilina, Alexandra, Van Der Brug, Marcel, Ahmad, Rili, Kesavapany, Sashi, Miller, David W., Petsko, Gregory A., Cookson, Mark R.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2005
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC556294/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15824318/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0500617102
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