Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases

Mutations in LRRK2 are the most common genetic cause of Parkinson's disease (PD). The most prevalent LRRK2 mutation is the G2019S coding change, located in the kinase domain of this complex multi-domain protein. The majority of G2019S autopsy cases feature typical Lewy Body pathology with a clinical...

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Auteurs principaux:	Adamantios Mamais, Meera Raja, Claudia Manzoni, Sybille Dihanich, Andrew Lees, Darren Moore, Patrick A. Lewis, Rina Bandopadhyay
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2013-10-01
Collection:	Neurobiology of Disease
Sujets:	LRRK2 G2019S α-Synuclein Differential solubility Immunohistochemistry
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S0969996113001599
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