Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability

Several mutations in PTEN-induced putative kinase 1 (PINK1) gene have been reported to be associated with recessive parkinsonism. The encoded protein is predicted to be a Ser/Thr protein kinase targeted to mitochondria. In this study, we have investigated the effects of mutations on PINK1 kinase act...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Beilina, Alexandra, Van Der Brug, Marcel, Ahmad, Rili, Kesavapany, Sashi, Miller, David W., Petsko, Gregory A., Cookson, Mark R.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2005
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC556294/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15824318/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0500617102
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