Cytotoxicity of Thiazolidinedione-, Oxazolidinedione- and Pyrrolidinedione-Ring Containing Compounds in HepG2 Cells

Liver damage occurred in some patients who took troglitazone (TGZ) for type II diabetes. The 2,4-thiazolidinedione (TZD) ring in TGZ's structure has been implicated in its hepatotoxicity. To further examine the potential role of a TZD ring in toxicity we used HepG2 cells to evaluate two series...

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Publicat a:Toxicol In Vitro
Autors principals: Keil, Alyssa M., Frederick, Douglas M., Jacinto, Erina Y., Kennedy, Erica L., Zauhar, Randy J., West, Nathan M., Tchao, Ruy, Harvison, Peter J.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5561654/
https://ncbi.nlm.nih.gov/pubmed/26193171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tiv.2015.07.015
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