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Role of Biotransformation in 3-(3,5-Dichlorophenyl)-2,4-thiazolidinedione-induced Hepatotoxicity in Fischer 344 Rats

Cytochrome P450 (CYP)-mediated metabolism in the thiazolidinedione (TZD) ring may contribute to the hepatotoxicity of the insulin-sensitizing agents such as troglitazone. We were interested in determining if biotransformation could also be a factor in the liver damage associated with another TZD rin...

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Hlavní autoři: Crincoli, Christine M., Patel, Niti N., Tchao, Ruy, Harvison, Peter J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570351/
https://ncbi.nlm.nih.gov/pubmed/18621092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2008.06.006
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