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Evaluation of analgesia, tolerance and the mechanism of action of morphine-6-O-sulfate across multiple pain modalities in Sprague-Dawley rats
BACKGROUND: Morphine-6-O-sulfate (M6S) is a mixed μ-/δ-opioid receptor (OR) agonist and potential alternative to morphine for treatment of chronic multimodal pain. METHOD: To provide more support for this hypothesis, the antinociceptive effects of M6S and morphine were compared in tests that access...
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| Publicat a: | Anesth Analg |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5561516/ https://ncbi.nlm.nih.gov/pubmed/28489639 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1213/ANE.0000000000002006 |
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