Novel STAT binding elements mediate IL-6 regulation of MMP-1 and MMP-3

Dynamic remodelling of the extracellular matrix (ECM) is a key feature of cancer progression. Enzymes that modify the ECM, such as matrix metalloproteinases (MMPs), have long been recognised as important targets of anticancer therapy. Inflammatory cytokines are known to play a key role in regulating...

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Publicado en:Sci Rep
Main Authors: Cutler, Samuel J., Doecke, James D., Ghazawi, Ibtisam, Yang, Jinbo, Griffiths, Lyn R., Spring, Kevin J., Ralph, Stephen J., Mellick, Albert S.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5561029/
https://ncbi.nlm.nih.gov/pubmed/28819304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08581-y
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