JAK/STAT regulation of Aspergillus fumigatus corneal infections and IL-6/23-stimulated neutrophil, IL-17, elastase, and MMP9 activity

IL-6 and IL-23 (IL-6/23) induce IL-17A (IL-17) production by a subpopulation of murine and human neutrophils, resulting in autocrine IL-17 activation, enhanced production of reactive oxygen species, and increased fungal killing. As IL-6 and IL-23 receptors trigger JAK1, -3/STAT3 and JAK2/STAT3 phosp...

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Bibliographische Detailangaben
Veröffentlicht in:J Leukoc Biol
Hauptverfasser: Taylor, Patricia R., Roy, Sanhita, Meszaros, Evan C., Sun, Yan, Howell, Scott J., Malemud, Charles J., Pearlman, Eric
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Leukocyte Biology 2016
Schlagworte:
Host Defense & Pathophysiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946614/
https://ncbi.nlm.nih.gov/pubmed/27034404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.4A1015-483R
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