JAK/STAT regulation of Aspergillus fumigatus corneal infections and IL-6/23-stimulated neutrophil, IL-17, elastase, and MMP9 activity

IL-6 and IL-23 (IL-6/23) induce IL-17A (IL-17) production by a subpopulation of murine and human neutrophils, resulting in autocrine IL-17 activation, enhanced production of reactive oxygen species, and increased fungal killing. As IL-6 and IL-23 receptors trigger JAK1, -3/STAT3 and JAK2/STAT3 phosp...

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Detalhes bibliográficos
Publicado no:J Leukoc Biol
Main Authors: Taylor, Patricia R., Roy, Sanhita, Meszaros, Evan C., Sun, Yan, Howell, Scott J., Malemud, Charles J., Pearlman, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Leukocyte Biology 2016
Assuntos:
Host Defense & Pathophysiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946614/
https://ncbi.nlm.nih.gov/pubmed/27034404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.4A1015-483R
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