Leptin increase in multiple sclerosis associates with reduced number of CD4(+)CD25(+) regulatory T cells

We analyzed the serum and cerebrospinal fluid (CSF) leptin secretion and the interaction between serum leptin and CD4(+)CD25(+) regulatory T cells (T(Regs)) in naïve-to-therapy relapsing-remitting multiple sclerosis (RRMS) patients. Leptin production was significantly increased in both serum and CSF...

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Autori principali: Matarese, Giuseppe, Carrieri, Pietro Biagio, La Cava, Antonio, Perna, Francesco, Sanna, Veronica, De Rosa, Veronica, Aufiero, Daniela, Fontana, Silvia, Zappacosta, Serafino
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2005
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC555982/
https://ncbi.nlm.nih.gov/pubmed/15788534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0408995102
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