Leptin modulates autophagy in human CD4(+)CD25(−) conventional T cells

OBJECTIVE: In this report we show that the adipocytokine leptin directly modulates autophagy in human CD4(+)CD25(−) conventional (Tconv) T cells. RESULTS: In vitro treatment with recombinant human leptin determined an inhibition of autophagy during T cell receptor (TCR) stimulation, and this phenome...

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Autors principals: Cassano, Silvana, Pucino, Valentina, La Rocca, Claudia, Procaccini, Claudio, De Rosa, Veronica, Marone, Gianni, Matarese, Giuseppe
Format: Artigo
Idioma:Inglês
Publicat: W.B. Saunders 2014
Matèries:
Clinical Science
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180014/
https://ncbi.nlm.nih.gov/pubmed/25060689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.metabol.2014.06.010
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