Chromatin accessibility landscape of cutaneous T cell lymphoma and dynamic response to HDAC inhibitors

Here, we define the landscape and dynamics of active regulatory DNA in cutaneous T cell lymphoma (CTCL) by ATAC-seq. Analysis of 111 human CTCL and control samples revealed extensive chromatin signatures that distinguished leukemic, host, and normal CD4(+) T cells. We identify three dominant pattern...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Qu, Kun, Zaba, Lisa C., Satpathy, Ansuman T., Giresi, Paul G., Li, Rui, Jin, Yonghao, Armstrong, Randall, Jin, Chen, Schmitt, Nathalie, Rahbar, Ziba, Ueno, Hideki, Greenleaf, William J., Kim, Youn H., Chang, Howard Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5559384/
https://ncbi.nlm.nih.gov/pubmed/28625481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.05.008
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