Epigenetic Regulation of KPC1 Ubiquitin Ligase Effects the NF-κB Pathway in Melanoma

PURPOSE: Abnormal activation of the NF-κB pathway induces a more aggressive phenotype of cutaneous melanoma. Understanding the mechanisms involved in melanoma NF-κB activation may identify novel targets for this pathway. KPC1, an E3 ubiquitin ligase, is a regulator of NF-κB pathway. The objective of...

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Bibliografski detalji
Izdano u:Clin Cancer Res
Glavni autori: Iida, Yuuki, Ciechanover, Aaron, Marzese, Diego M., Hata, Keisuke, Bustos, Matias, Ono, Shigeshi, Wang, Jinhua, Salomon, Matthew P., Tran, Kevin, Lam, Stella, Hsu, Sandy, Nelson, Nellie, Kravtsova-Ivantsiv, Yelena, Mills, Gordon B., Davies, Michael A., Hoon, Dave S.B.
Format: Artigo
Jezik:Inglês
Izdano: 2017
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5559338/
https://ncbi.nlm.nih.gov/pubmed/28389511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-0146
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