MicroRNA-93 activates c-Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A

To assess the role of microRNAs (miR) in hepatocellular carcinoma (HCC), we performed comprehensive microRNA expression profiling using HCC cell lines and identified miR-93 as a novel target associated with HCC. We further verified miR-93 expression levels in advanced HCC tumors (n=47) by a direct P...

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Pubblicato in:Oncotarget
Autori principali: Ohta, Katsuya, Hoshino, Hiromitsu, Wang, Jinhua, Ono, Shigeshi, Iida, Yuuki, Hata, Keisuke, Huang, Sharon K., Colquhoun, Steven, Hoon, Dave S. B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2014
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413648/
https://ncbi.nlm.nih.gov/pubmed/25633810
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