CDCP1 drives triple-negative breast cancer metastasis through reduction of lipid-droplet abundance and stimulation of fatty acid oxidation

Triple-negative breast cancer (TNBC) is notoriously aggressive with high metastatic potential, which has recently been linked to high rates of fatty acid oxidation (FAO). Here we report the mechanism of lipid metabolism dysregulation in TNBC through the prometastatic protein, CUB-domain containing p...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Wright, Heather J., Hou, Jue, Xu, Binzhi, Cortez, Marvin, Potma, Eric O., Tromberg, Bruce J., Razorenova, Olga V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2017
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PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5559020/
https://ncbi.nlm.nih.gov/pubmed/28739932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1703791114
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