CDCP1 drives triple-negative breast cancer metastasis through reduction of lipid-droplet abundance and stimulation of fatty acid oxidation

Triple-negative breast cancer (TNBC) is notoriously aggressive with high metastatic potential, which has recently been linked to high rates of fatty acid oxidation (FAO). Here we report the mechanism of lipid metabolism dysregulation in TNBC through the prometastatic protein, CUB-domain containing p...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Wright, Heather J., Hou, Jue, Xu, Binzhi, Cortez, Marvin, Potma, Eric O., Tromberg, Bruce J., Razorenova, Olga V.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5559020/
https://ncbi.nlm.nih.gov/pubmed/28739932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1703791114
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