Fatty acid amide hydrolase–morphine interaction influences ventilatory response to hypercapnia and postoperative opioid outcomes in children

AIM: Fatty acid amide hydrolase (FAAH) degrades anandamide, an endogenous cannabinoid. We hypothesized that FAAH variants will predict risk of morphine-related adverse outcomes due to opioid–endocannabinoid interactions. PATIENTS & METHODS: In 101 postsurgical adolescents receiving morphine anal...

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Dades bibliogràfiques
Publicat a:Pharmacogenomics
Autors principals: Chidambaran, Vidya, Pilipenko, Valentina, Spruance, Kristie, Venkatasubramanian, Raja, Niu, Jing, Fukuda, Tsuyoshi, Mizuno, Tomoyuki, Zhang, Kejian, Kaufman, Kenneth, Vinks, Alexander A, Martin, Lisa J, Sadhasivam, Senthilkumar
Format: Artigo
Idioma:Inglês
Publicat: Future Medicine Ltd 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5558540/
https://ncbi.nlm.nih.gov/pubmed/27977335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/pgs-2016-0147
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