Alteration of sheep coat color pattern by disruption of ASIP gene via CRISPR Cas9

Coat color is an important characteristic and economic trait in domestic sheep. Aiming at alteration of Chinese merino sheep coat color by genome manipulation, we disrupted sheep agouti signaling protein gene by CRISPR/Cas9. A total of seven indels were identified in 5 of 6 born lambs. Each targeted...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Zhang, Xuemei, Li, Wenrong, Liu, Chenxi, Peng, Xinrong, Lin, Jiapeng, He, Sangang, Li, Xuejiao, Han, Bing, Zhang, Ning, Wu, Yangsheng, Chen, Lei, Wang, Liqin, MaYila, Huang, Juncheng, Liu, Mingjun
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2017
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5557758/
https://ncbi.nlm.nih.gov/pubmed/28811591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08636-0
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