Alteration of sheep coat color pattern by disruption of ASIP gene via CRISPR Cas9

Coat color is an important characteristic and economic trait in domestic sheep. Aiming at alteration of Chinese merino sheep coat color by genome manipulation, we disrupted sheep agouti signaling protein gene by CRISPR/Cas9. A total of seven indels were identified in 5 of 6 born lambs. Each targeted...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Zhang, Xuemei, Li, Wenrong, Liu, Chenxi, Peng, Xinrong, Lin, Jiapeng, He, Sangang, Li, Xuejiao, Han, Bing, Zhang, Ning, Wu, Yangsheng, Chen, Lei, Wang, Liqin, MaYila, Huang, Juncheng, Liu, Mingjun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5557758/
https://ncbi.nlm.nih.gov/pubmed/28811591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08636-0
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