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RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system
A pair of kinases, RIPK1 and RIPK3, as well as the RIPK3 substrate MLKL cause a form of programmed necrotic cell death in mammals termed necroptosis. We report here that male reproductive organs of both Ripk3- and Mlkl-knockout mice retain ‘youthful’ morphology and function into advanced age, while...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5557593/ https://ncbi.nlm.nih.gov/pubmed/28807105 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27692 |
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