Optimization of Glioblastoma Mouse Orthotopic Xenograft Models for Translational Research

Glioblastoma is an aggressive primary brain tumor predominantly localized to the cerebral cortex. We developed a panel of patient-derived mouse orthotopic xenografts (PDOX) for preclinical drug studies by implanting cancer stem cells (CSC) cultured from fresh surgical specimens intracranially into 8...

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Pubblicato in:Comp Med
Autori principali: Irtenkauf, Susan M, Sobiechowski, Susan, Hasselbach, Laura A, Nelson, Kevin K, Transou, Andrea D, Carlton, Enoch T, Mikkelsen, Tom, deCarvalho, Ana C
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Association for Laboratory Animal Science 2017
Soggetti:
Mouse Models
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5557202/
https://ncbi.nlm.nih.gov/pubmed/28830577
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